Squamous cell carcinoma of the soft palate associated with autoantibodies to desmoglein 1 and 3
نویسندگان
چکیده
The desmogleins are a family of cadherins cell-cell adhesion molecules consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes, which form the major types of intercellular adhesive junctions. DSGs are currently thought to be involved in autoimmune diseases, infectious diseases, and inherited diseases. Patients with pemphigus, an autoimmune blistering disease of the skin and mucous membranes, carry IgG autoantibodies directed against DSG1 and DSG3 [1]. Pemphigus vulgaris antigen is also considered a tissue-specific type of desmoglein [1].
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